Single Sample CNV/LOH Analysis and Visualization with Nexus Solo

In this presentation we will show how to analyze CGH/SNP array data from a single sample to uncover gains/losses, LOH/allelic events, and correlate with data from external databases such as the DGV. For this demonstration, we will use the newly released version 6.0 of Nexus Solo (a complementary product to Nexus Copy Number 6.0 but limited to review of one sample at a time). We will also show how to use Nexus DB 6.0 (a free web-based repository integrated with Nexus Solo) and Nexus Solo Reader Clients in combination with Nexus Solo to form a powerful collaborative tool.   We will demonstrate how data from any array platform can be loaded and processed to automatically identify regions of copy number change and LOH. Navigation of the genome to review the regions is fully interactive providing for manual adjustments (adding/adjusting regions and applying classification to regions) and creating customized reports with notes and annotations. The flexible design within Nexus allows users to add their own annotation tracks and link out to numerous public databases to search for information about regions and genes. We will demonstrate how one individual can load and process data using Nexus Solo and easily make accessible the results in Nexus DB to multiple users for review via Nexus Solo Reader Clients (Nexus Solo Reader is free for Academics).

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