Gene Enrichment Analysis Module
Overview plot showing both copy number aberrations and allelic Events. The blue and red bars next to the ideograms depict gain and loss regions respectively and the allelic event aberrations are shown with the gold (LOH) and purple (allelic imbalance) highlighting on the ideograms.
Integrating different modalities allows for a more comprehensive analysis of a project. The external data module does that by integrating miRNA, mRNA, and methylation results with copy number and allelic events to identify genomic “hot spots” of change. It shows the overlapping areas of changes (between gene expression results and copy number changes, for example) that are unlikely to happen by chance alone and provides easy access to associated genes, and functions in such regions.
Features
- Enrichment over the whole genome identifying genes/pathways enriched with a high degree of copy number change over the genome.
- Enrichment on selected regions using pre-defined gene list (those genes coincident with the selected aberrant regions).
