Nexus Copy Number – Accelerating Copy Number Analysis Research

Nexus Copy Number simplifies genetic aberration analysis with an elegant and simple user interface, efficient processing for rapid and automated analysis of thousands of arrays, and a flexible design that accommodates user preferences such as custom annotation tracks, integration of custom databases (e.g. CNVs, genetic disorders), segmentation algorithm, and integration of miRNA and gene expression data. With detection of copy number and LOH events and flexibility in handling any commercial or custom array as well as any organism, Nexus Copy Number is the only solution you need for array based genetic aberration analysis. With a choice of two configurations (Standard or Discovery Editions), Nexus Copy Number meets the needs of any investigator.

Compare Editions

		Standard	Discovery
Flexible data type and experiment design support
Platform independent – support for all array platforms and associated software including Affymetrix®, Agilent®, Illumina®, Roche NimbleGen®, GenePix®, ImaGene®, and more
Support for any organism
Support for dye-swap experiments
Processing
Efficient processing for 1000s of arrays
Support for other calling algorithms
Sample QC
Aberration detection
Copy number change identification
Allelic event calling for SNP arrays (e.g. LOH)
Identification of common areas and minimal common areas of aberrations
Identify statistically significant frequency peaks in a population
Results reporting
Customized sample reports
High resolution publication ready images
Integration with public and custom databases
Link to external databases (e.g. NCBI, Ensemble, DECIPHER)
Annotation tracks for genes, exons, miRNAs, CNVs
Custom annotation tracks
Custom CNV database support
Data exploration
Integration of phenotype/clinical data (factors)
Display of aberration frequency by phenotype or factor subgroups
Factor enrichment
Ability to query all samples based on genes or genomic locations
Identification of regions of statistically significant difference between sample populations
Identification of regions with statistically significant predictive power on numeric phenotypes
Survival analysis (Kaplan Meir plots and significance values)
Clustering of samples based on genomic change
Gene ontology enrichment analysis
Integration of external data
Gene and miRNA expression results integration

White Papers

• High Resolution Copy Number Analysis of Parkinson’s Samples Using Nexus Copy Number and Roche NimbleGen Microarrays
• Copy Number Analysis of Head and Neck cancer

Recent Publications

A de-novo 7.6 Mb tandem duplication of 14q32.2-qter associated with primordial short stature with neurosecretory growth hormone dysfunction, distinct facial anomalies and mild developmental delay
Thiel CT, Dörr HG, Trautmann U, Hoyer J, Hofmann K, Kraus C, Ekici AB, Reis A, Rauch A. Eur J Med Genet. 2008 Jul-Aug; 51(4):362-7. Epub 2008 Mar 20. [PubMed]

Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia
Tom Walsh, Jon M. McClellan, Shane E. McCarthy, Anjene M. Addington, Sarah B. Pierce, Greg M. Cooper, Alex S. Nord, Mary Kusenda, Dheeraj Malhotra, Abishek Bhandari, Sunday M. Stray, Caitlin F. Rippey, Patricia Roccanova, Vlad Makarov, B. Lakshmi, Robert L. Findling, Linmarie Sikich, Thomas Stromberg , Barry Merriman, Nitin Gogtay, Philip Butler, Kristen Eckstrand, Laila Noory, Peter Gochman, Robert Long, Zugen Chen, Sean Davis, Carl Baker, Evan E. Eichler, Paul S. Meltzer, Stanley F. Nelson, Andrew B. Singleton, Ming K. Lee, Judith L. Rapoport, Mary-Claire King, Jonathan Sebat. Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science, 27 March 2008. (10.1126/science.1155174). [Abstract]

Multiple sub-microscopic genomic lesions are a universal feature of chronic myeloid leukaemia at diagnosis
J S Khorashad, V A De Melo, H Fiegler, G Gerrard, D Marin, J F Apperley, J M Goldman, L Foroni and A G Reid. Leukemia (2008) 22, 1806–1807. (10.1038/leu.2008.210) [Abstract] [PubMed]

Customized Oligonucleotide Array-Based Comparative Genomic Hybridization as a Clinical Assay for Genomic Profiling of Chronic Lymphocytic Leukemia
Rachel Sargent, Dan Jones, Lynne V. Abruzzo, Hui Yao, Jaime Bonderover, Marissa Cisneros, William G. Wierda, Michael J. Keating and Rajyalakshmi Luthra. Journal of Molecular Diagnostics 2009, Vol. 11, No. 1. (10.2353/jmoldx.2009.080037) [Abstract]

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System Requirements

Platforms Supported: Windows Win2k/WinXP, OS X
Minimum: 1.0 GHz Pentium or G4, 512 MB RAM
Recommended: 2.0 GHz or faster Core 2 Duo, 1024 or more MB RAM

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Contact BioDiscovery today to request a free trial, receive a quote or request additional information.

NOTE: This product is for Research Use Only