BioDiscovery is pleased to provide copies of previously recorded webinars to customers and colleagues. Webinars will be posted based upon interest and feedback from attendees. If you encounter any problems watching the videos simply contact us via the form here for assistance.
Upcoming Webinars
Recent Webinar Video
Constitutional and Cancer Sample Review for Cytogeneticists: Copy Number and Sequence Variant Analysis Using Nexus Copy Number 7
Description
In this presentation we will demonstrate CNV, LOH and sequence variant analysis tools for cytogeneticists which will accelerate their sample review workflow and allow for better decisions on the significance of events being detected. Using <a title=”For Cytogenetics” href=”http://www.biodiscovery.com/software/nexus-copy-number/for-cytogenetics/”>Nexus Copy Number</a> 7 as a platform independent solution for analysis and visualization of CNV, LOH, and sequence variation, we will review individual case examples for both constitutional and cancer samples. We will demonstrate how data from any platform can be loaded and processed to automatically identify regions of copy number change and LOH. Enhanced filtering options and quick comparison with online public databases (e.g. ISCA, AGRE, TCGA) in Nexus Copy Number 7 allows for quick creation of customized reports with notes and annotations. Finally, we will co-visualize sequence variation results with copy number calls for samples with data from multiple modalities for integrated genomic evaluation.
Audience
This webinar is geared towards cytogeneticists performing CNV, LOH, and sequence variant analysis from aCGH, SNP array, and NGS data. Existing Nexus users will benefit from learning about the new features in the new version 7 of Nexus Copy Number and Nexus Solo and how to use them effectively.
Webinar Archives
Integrated analysis of sequence variations and copy number in TCGA data with the new Nexus Copy Number 7
Description
In this webinar, we will present an integrated analysis of copy number and sequence variation using data from The Cancer Genome Atlas (TCGA). TCGA data is publicly available via the TCGA portal and includes copy number data and whole exome sequencing data. Nexus Copy Number 7 has a number of new features including support for sequence variations (in various formats including VCF, MAF, and Affymetrix OncoScan somatic mutation files). Other new features particularly applicable to cancer studies are identification of co-occurrent regions and ASCAT2. Using the Discovery Edition of Nexus Copy Number 7.0, we will present findings which include: identification of areas of copy number enrichment using GISTIC analysis, identification of frequently mutated genes, comparison of copy number profiles between groups of tumors within the sample set, determination of co-occurrence between specific sequence variation and copy number alterations, and survival analysis.
Audience
This webinar is geared towards researchers interested how CNV, allelic events, and seq. variations can aid in the discovery process in cancer studies.
Educational Webinar Series – Copy Number Analysis and Its Application to Genomic Research: Data QC, GC Wave Correction and Mosaicism
This is the second webinar of a new educational series where we go from the very basics of copy number analysis to more advanced analysis topics. Fundamental concepts such as copy number measurement methods, quality assessment, and different approaches/algorithms used for detecting copy number changes and allelic events as well as unique complications encountered in different applications will be presented.
Today’s webinar will cover the following three mini-courses:
- Data QC – learn about the different quality measures, how the quality score is calculated, and how to determine what is a good quality score.
- Systematic bias correction (GC wave correction) – identifying systematic biases in your data, different correction approaches, and when and how to apply such correction methods.
- Mosaicism and its effect on aCGH measurements – what is mosaicism, how to identify it, and how it affects the calling algorithms
Audience
This webinar is geared towards those who want to learn the fundamentals of copy number variation analysis.
Copy number variation has increasingly been recognized as an important cause of human disease phenotypes. Detection of copy number variants (CNVs) has become a routine clinical practice for patients exhibiting developmental delay and other neurocognitive phenotypes. However, before cause and effect connections can be made, and clinical management altered, copy number variants (CNVs) must be accurately detected and thoroughly annotated by the laboratory performing the testing…
In this new series of webinars, held over the next few months, we will sequentially transition from the very basics of copy number analysis to more advanced analysis topics. Fundamental concepts such as copy number measurement methods, quality assessment, and different approaches/algorithms used for detecting copy number changes and allelic events as well as unique complications encountered in different applications will be presented….
The Cancer Genome Atlas (TCGA) has generated a wealth of genomic information for a wide range of cancers. Much of the data is available publicly on the internet via the TCGA portal. Although the data portal provides access to download processed data as well as the ability to issue simple queries, the utility of this tool is rather limited for most research applications….
Genetic studies of various diseases and disorders requires researchers to sift through vast amounts of accumulated data from diverse sources in order to identify key factors that play a role in these disorders. Having the right tools makes all the difference in processing the data efficiently to accelerate discovery…
Analyzing copy number variation in cancer tissues can be a difficult task due to the heterogeneity of the cell population. In this presentation, we will show how to evaluate a population of tumor samples using ASCAT …
The challenges of formalin-fixed, paraffin-embedded (FFPE) samples hinder many cancer researchers looking to unlock archival samples with retrospective clinical data. Standard array CGH methods result in high sample failure rates and low dynamic range, require a high amount of input DNA, and provide only relative copy number information…
In this presentation, we describe a software workflow that allows investigators to easily and effectively utilize this valuable tool as part of the standard sample review process……
While copy number estimation is not often the primary goal of either exome or whole-genome sequencing, it does augment the view of the genome provided by SNVs and small insertions and deletions. Particularly in cancer, where disordered genomes are common, the copy number layer adds biological context that is important in understanding tumor biology…
In this presentation we will present the effective use of Nexus Copy Number software for rapid and efficient exploration of genomic change in large scale studies…
Integration of genomic data from different modalities (e.g. copy number variation, gene expression, miRNA expression, etc.) is a major area of interest with the growing ability to extract such information using high throughput methods such as microarrays…
In this presentation we will demonstrate the power of Nexus Expression in simplifying the process of data exploration and visualization in gene expression data obtained from various array technologies. We will highlight new features in upcoming new version (v. 3.0)…
In this presentation we will demonstrate the power of Nexus Expression in simplifying the process of data exploration and visualization in gene expression data obtained from various array technologies…
In this presentation we will show how to analyze CGH/SNP array data from a single sample to uncover gains/losses, LOH/allelic events, and correlate with data from external databases such as the DGV…
In this presentation we will cover many new enhancements to Nexus DB that will be part of the version 6 release. These enhancements are designed to offer users more autonomy in creating groups, enhanced controls over data access rights, graphical display of query results and much more…
In this presentation we will demonstrate CNV and LOH analysis tools that will help cytogeneticists speed up their process of reviewing samples and make better decisions on the significance of events being detected . The Nexus Copy Number is a platform independent solution for analysis and visualization of CNV and LOH from CGH and SNP arrays…
We will examine and show how to answer certain biological questions using Nexus Copy Number. This is not a software demo such as a general introduction to Nexus Copy Number software nor is it a demonstration of software features…
Please join us for our inaugural webinar in a new webinar series (Array Data Analysis Tutorials) where we examine and show how to answer certain biological questions using Nexus Copy Number…
Analyzing copy number variation in cancer tissues can be a difficult task due to the heterogeneity of the cell population. The soon to be released version 6.0 of Nexus Copy Number has a number of new tools that will help address these issues…
In this webinar we present analysis of ovarian cancer highlighting features such as class comparisons and gene enrichment found in the Discovery Edition of Nexus Copy Number 5.0…
Please join us for our inaugural webinar in a new webinar series (Array Data Analysis Tutorials) where we examine and show how to answer certain biological questions using Nexus Copy Number…
In this presentation we utilize data from a recently published paper by Nancarrow et. al (Cancer Research 2008) in which a set of 23 esophageal adenocarcinoma (EAC) primary tumor biopsies were analyzed using Illumina Sentrix HumanHap300 BeadChip arrays…
The application of aCGH and next generation sequencing technologies to the analysis of prostate tumor genomes and transcriptomes for identification of biomarkers and therapeutic targets will be discussed. Special challenges associated with analyzing NGS and microarray data and their integration with diverse data sets will be discussed…