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ASCAT (Allele-Specific Copy number Analysis of Tumors) developed by Peter Van Loo was created to essentially automate discovery of ploidy and percent normal contamination in tumor samples and relies on B-allele frequencies from SNP array data to make these estimates. The video reviews what the ASCAT algorithm does and how it accounts for complications of aneuploidy, tumor heterogeneity, and contamination from normal cells in tumor sample analysis.