Curated CNVs, Sequence Variants, Simplified Access.
The Cancer Genome Atlas (TCGA) is an amazing resource, growing to contain genomic profiles of approaching 12,000 tumors across more than thirty cancer types. By re-analyzing the data and manually curating the results of each sample by trained scientists, the TCGA Premier database has the highest fidelity copy number information from this rich resource.
Why TCGA Premier?
Useful for a wider range of studies
Processing GISTIC samples produced results suited for population-wide profiles, but left individual samples over-segmented and many having incorrect ploidy. By correcting these, and integrating sequence variants, we have enabled the data set to become more useful for studies such as survival analysis or tumor sub-type profiling.
Simplified Access via Nexus Copy Number
TCGA Premier is already integrated with Nexus Copy Number software, allowing users to quickly query the database, retrieve samples of interest along with annotations, and perform further analysis all through the Nexus interface.
Improved Copy Number profiles
Each sample is re-processed from the “raw” (i.e., level 1) data, then manually reviewed by a team of scientists ensuring the highest fidelity CNV calls. To further enhance usability, samples with complex tumor profiles are “flagged” for the researcher, as are suspected chromothriptic events. Samples with poor quality that introduce statistical noise are removed.