This video covers CNV calling algorithms. Common approaches, HMM (Hidden Markov Model), CBS (circular binary segmentation), and Rank Segmentation are covered along with a discussion of the pros and cons of each algorithm.
- How to use the BAM algorithm to obtain both copy number and allelic events from NGS data (unique and exclusive to Nexus Copy Number)
- Why this Read-Depth method is the most reliable and efficient means to extracting copy number information out of NGS data
- How the algorithm compares to other CNV estimating algorithms such as CoNIFER and XHMM