New software feature Automated Genomic Scar Analysis for HRD with NxClinical Software

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Enhanced transparency and clarity of chromosomal abnormalities to enable more accurate analysis of genomic scar instability Click to enlarge screen in new tab »

Bionano's NxClinicalTM Software is the leading copy number variation (CNV) analysis software solution for cytogenetics and molecular laboratories. The latest software (v6.2) release adds three measures of genomic instability for homologous recombination repair deficiency (HRD) in solid tumors:

  • Loss of heterozygosity (LOH)
  • Telomeric Allelic Imbalance (TAI)
  • Large-Scale State Transitions (LST)

There are three processing steps involved in calculating these scores:

  1. Detecting CN and LOH events from arrays and next-generation sequencing (NGS)
  2. Merging and smoothing similar event types
  3. Selecting the resulting calls or breakpoints that comply with each scar’s specifications

NxClinical provides an automated, totaling of LOH, TAI, and LST allowing for rapid data analysis during case review. Results must then be verified by a qualified clinician.

To learn more about this NxClinical feature, download our free white paper: Automating Genomic Scar Analysis for HRD: A Solution for Clinical Research Labs

Get the white paper »


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Learn more about HRD and NxClinical automated analysis during this recent webinar

🎬Next-Generation Sequencing (NGS) Assessment of Homologous Recombination Deficiency (HRD): Expanding NGS Data to View Events Associated with Genomic Instability

Presented by:

Dr. Christopher Lum, M.D.
Medical Director, Molecular Diagnostics Laboratory at Diagnostic Laboratory Services, Inc.
Zan Halford, M.S. SMB(ASCP)CM,
Medical Technologist, Diagnostic Laboratory Services, Inc.

Watch the Webinar

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Read more about the HRD Harmonization Project from Friends of Cancer Research

📰Homologous Recombination Deficiency: Concepts, Definitions, and Assays

Read Publication

Get the software trusted by renowned academic and commercial clinical labs to stay on top of demanding, time-sensitive workloads.

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Genome-wide tumor profiles can answer HRD questions.

white paper featured imagesSubmit the form below to access our free HRD white paper. You’ll learn how Bionano's new automated genomic scar analysis tool can let you efficiently analyze this emerging biomarker in tumor samples.